The .gov means its official. This rash is thought to be caused by a virus. The authors have no conflicts of interest to declare. Due to the temporal relationship between vaccination and onset of rash, COVID-19 vaccination was the most likely etiology. COVID-19; HHV, human herpes virus; Moderna; PR; PR, pityriasis rosea; PR-LE; PR-LE, pityriasis rosea-like eruption; Pfizer; coronavirus; dermatology; mRNA vaccine; mRNA, messenger RNA; pityriasis rosea; pityriasis rosealike eruption; vaccine. Patient concerns: Hum Vaccin Immunother. Parakeratosis with minimal acanthosis and spongiosis of the epidermis. Before 2005;124(6):12341240. 1 Several vaccines have been developed to fight against COVID19, to prevent the transmission among susceptible individuals and to decrease the morbidity Do the medications have any side effects? Safety and efficacy of the BNT162b2 mRNA Covid19 vaccine. Epub 2020 Jun 5. doi: 10.7759/cureus.22414. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. and transmitted securely. Is there a prescription cream or ointment that you can prescribe? Disclaimer. Here, we describe a case of PR-like eruption following ChAdOx1 nCoV-19 (AZD1222) vaccination in a Thai patient with glioblastoma. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Birlutiu V, Dobritoiu ES, Lupu CD, Herteliu C, Birlutiu RM, Dragomirescu D, Vorovenci A. Pityriasis rosea developing after COVID-19 vaccination. The following self-care tips may help relieve the discomfort of pityriasis rosea: Take nonprescription allergy medicine (antihistamines), such as diphenhydramine (Benadryl, others). Some rare cases can take up to three months. Advertising on our site helps support our mission. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. Pityriasis Rosea Following Pfizer-BioNTech Vaccination in an Adolescent Girl. (A) Dermoscopic features: dotted and linear vessels forming a network on a yellowish background with some whitish peripheral scales (original magnification x20). However, adverse effects to COVID-19 vaccines, particularly cutaneous reactions, have been reported. J Eur Acad Dermatol Venereol. Suchonwanit P, Triamchaisri S, Wittayakornrerk S, Rattanakaemakorn P. Leprosy Reaction in Thai Population: A 20-Year Retrospective Study. Interventions: 2022 Aug 11;9(8):43. doi: 10.3390/medicines9080043. Pityriasis rosea is a common condition that causes discolored patches on your skin. Epub 2022 May 31. doi: 10.1159/000517971. doi: 10.1111/jdv.17342. 2022 Mar 9;35(3):342-343. doi: 10.1080/08998280.2022.2044742. Drago F, Ciccarese G, Javor S, Parodi A. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. J Eur Acad Dermatol Venereol 2020;34:e4367. Disclaimer. 2022 by the American Academy of Dermatology, Inc. J Med Virol 2021; 93: 1850-1851. Dermatol Online J. and transmitted securely. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. Australas J Dermatol. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. Epub 2022 Feb 9. The patients/participants provided their written informed consent to participate in this study. It could be pityriasis rosea here's how to treat it. Moreover, central dusky-red erythematous was observed on some plaques (Figure 2A). 1. Fortunately, PR-like eruption is responsive to topical corticosteroids without any systemic adverse effects. 2022 Feb 20;14(2):e22414. (2016) 30:5445. Published by Elsevier Inc. Pityriasis rosea. FOIA Pityriasis rosea often occurs this way, but not always. Epub 2022 Jun 21. Your skin may develop discolored patches (lesions) that look like scales or dry, crinkly paper. Epub 2022 Jun 14. official website and that any information you provide is encrypted Accessibility The authors of one 2014 case report of a 71-year-old man who suffered from pityriasis rosea one month after receiving an influenza vaccine concluded that "altered immunity" could result in reactivation of HHV-6 and/or HHV-7 which may have triggered an atypical presentation of PR. Unable to load your collection due to an error, Unable to load your delegates due to an error. Although the exact pathogenesis of PR is unknown, current evidence suggests that an inflammatory reaction due to a viral trigger may lead to the cutaneous manifestations. While my particular flare-up itched a lot, that's not always the case. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Epub 2021 Jun 10. Would you like email updates of new search results? Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. COVID-19; SARS-CoV-2; pityriasis rosea; vaccination. The typical distribution of the rash is on the trunk between the neck and the knees.". Cutis. 2022 Oct;123:58-69. doi: 10.1016/j.ijid.2022.06.037. -, Neoh CY, Tan AW, Mohamed K, et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. Pityriasis rosea: An update on etiopathogenesis and management of difficult aspects. She diagnosed it as pityriasis rosea, a benign but frustratingly itchy rash that in her words just happens sometimes. National Library of Medicine World J Clin Cases. Pityriasis Rosea According to the Mayo Clinic, pityriasis rosea is a rash that usually begins as a large circular or oval spot on your chest, abdomen, or back. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. To the best of our knowledge, only one case of ChAdOx1 nCoV-19 vaccine-induced PR-like eruption has been reported (2). Figure 2. Epub 2022 Jun 21. J Eur Acad Dermatol Venereol. In approximately 50% of people with pityriasis rosea, the patches itch. Epub 2022 May 3. J Am Acad Dermatol. government site. KL and KP collated resources. (2006) 12:1. doi: 10.5070/D380D8301D, 11. 2021 Oct;20(10):3080-3084. doi: 10.1111/jocd.14372. Lastly, Hartman says PR can present differently in patients with darker skin: "The characteristic erythematous plaques may appear more hyperpigmented or violaceous in darker skin types. 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. Last reviewed by a Cleveland Clinic medical professional on 06/17/2022. The Covid Symptom Study. (2019) 34:185764. We present two cases of COVID-19 vaccine-induced pityriasis rosea. The authors have no conflicts of interests to disclose. sharing sensitive information, make sure youre on a federal Histopathological findings of pityriasis rosealike eruption in patient 1. National Library of Medicine This site needs JavaScript to work properly. Pityriasis Rosea Induced by COVID-19 Vaccination Eur J Case Rep Intern Med. You may be at risk of developing an allergic reaction on your skin. Please enable it to take advantage of the complete set of features! Of the 30 cases found, none experienced severe adverse effects and the rash resolved in an average of 5.6 weeks. Some people see the rash disappear within 6 to 8 weeks, but it can take 5 months or longer for the skin to clear. Cutis. Published by Wolters Kluwer Health, Inc. Atypical pityriasis rosea associated with mRNA COVID19 vaccine E. Bostan, Adam Jarbou Published 29 September 2021 Medicine Journal of Medical Virology Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of Covid-19. Herzum A, Trave I, D'Agostino F, Burlando M, Cozzani E, Parodi A. Clin Exp Vaccine Res. Studies show that some skin conditions may appear with COVID-19, including pityriasis rosea. Epub 2020 Nov 20. Various mild and benign cutaneous manifestations of the different forms of the COVID-19 vaccine have been documented. (Unfortunately, I scratched my rash until it bled, so my hyperpigmentation may linger.). 8600 Rockville Pike With COVID-19 vaccines being authorized for emergency use, monitoring for potential adverse effects (e.g., cutaneous reactions) is necessary. Pearls and pitfalls: Adverse cutaneous reactions after COVID-19 vaccination. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk. -, Carballido Vzquez A.M., Morgado B. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. It was described as "clinically reminiscent" of pityriasis rosea by the authors, from the divisions of dermatology and venereology, pathology, intensive care, and the virology laboratory, of the Hpital Cochin, Paris. Histopathologic features: (B) microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and interface dermatitis (hematoxylin-eosin; scale bar represents 100 m); (C) microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 m). Suchonwanit P, Rojhirunsakool S, Khunkhet S. A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia. 2022 Dec;9:127. doi: 10.1016/j.jdin.2022.03.018. Lasers Med Sci. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. These types cannot cause cold sores or genital herpes. MeSH sharing sensitive information, make sure youre on a federal PR is a rare cutaneous reaction after mRNA vaccination against SARS-CoV-2. Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. This site needs JavaScript to work properly. Disclaimer. J Eur Acad Dermatol Venereol. Drago F, Ciccarese G, Rebora A, Parodi A. Br J Dermatol. (2020) 33:e13650. -, Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosealike eruptions: how to distinguish them? Dermatol Reports. (2020) 33:e13878. The site is secure. headache.2 Several cutaneous adverse events after anti-COVID-19 vaccination are described in the literature, such as delayed large local reaction, urticaria, morbilliform eruptions, herpes zoster, "COVID arm," pityriasis rosea.3,4,5 Here, we report a case of a patient who presented with herpes zoster ophthalmicus (HZO) after the third dose Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. JAAD Int. Pityriasis rosea usually resolves on its own without treatment in most cases, King says, but topical corticosteroids can be used for itchy control if necessary, which is what I used. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk within days or weeks, says dermatologist Corey L. Hartman, founder of Skin Wellness Dermatology in Birmingham, Alabama.